ERβ-regulated circATP2B1/miR-204–3p/TWIST1 positive feedback loop facilitates epithelial to mesenchymal transition in clear cell renal cell carcinoma
Together, our results suggest that ERβ/circATP2B1/miR-204-3p/TWIST1 can promote EMT by forming a positive feedback loop, thus promoting the progression of ccRCC. Targeting this newly identified signaling pathway may more effectively control the progression of ccRCC.
Authors
- Zhenwei Han (ORCID: https://orcid.org/0000-0002-1247-7004)
- Pengfei Zhou (ORCID: https://orcid.org/0000-0003-1836-1122)
- Fengran Guo
- Kui Chi (ORCID: https://orcid.org/0000-0002-4643-4133)
- Hao Sun (ORCID: https://orcid.org/0000-0002-3670-2886)
- Xingyu He (ORCID: https://orcid.org/0000-0002-6098-9004)
- Bei Shi (ORCID: https://orcid.org/0000-0001-8063-9100)
- Ziyang Ma
- Yilong Gao
- Jiaqing Ye
- Yaxuan Wang
- Hu Wang
Institutions
- Hebei Medical University (CN)
- Sichuan University (CN)
- Third Hospital of Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- First Hospital of Shijiazhuang (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.tranon.2024.102213
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hebei Province
- Horizon 2020 Framework Programme