Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and ameliorates osteoarthritis progression
These findings highlight the potential of targeting ACSL4 in chondrocytes as a treatment strategy for OA, positioning PAE as a promising drug candidate.
Authors
- Ao Xiong
- Yaohang Yue (ORCID: https://orcid.org/0009-0003-4238-5527)
- Dongquan Shi (ORCID: https://orcid.org/0000-0002-4769-7816)
- Yihao Wei (ORCID: https://orcid.org/0000-0002-7636-0294)
- Siyang Cao (ORCID: https://orcid.org/0000-0001-7409-3746)
- Li Ye (ORCID: https://orcid.org/0000-0001-7688-4867)
- Jun Yang (ORCID: https://orcid.org/0000-0002-7016-6458)
- Deli Wang (ORCID: https://orcid.org/0000-0001-5032-2567)
- Hui Zeng (ORCID: https://orcid.org/0009-0003-9780-7459)
- Xiyu Liu (ORCID: https://orcid.org/0000-0002-3882-4609)
Institutions
- Hong Kong Polytechnic University (HK)
- Nanjing Drum Tower Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.jot.2024.10.005
- Citations
- 16
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 4.56