Determinants of tumor necrosis and its impact on outcome in patients with Localized osteosarcoma uniformly treated with a response adapted regimen without high dose Methotrexate– A retrospective institutional analysis
Patients of osteosarcoma with smaller tumor, lower serum alkaline phosphatase and earlier surgery are more likely to achieve favourable necrosis. Tumor necrosis independently predicts outcome in osteosarcoma, and response-adapted treatment escalation fails to overcome the adverse impact of poor necrosis in non-HDMTx based regimen.
Authors
- Sameer Bakhshi (ORCID: https://orcid.org/0000-0001-9367-4407)
- Shuvadeep Ganguly (ORCID: https://orcid.org/0000-0002-7296-6088)
- Deepam Pushpam (ORCID: https://orcid.org/0000-0001-8222-331X)
- Asit Ranjan Mridha (ORCID: https://orcid.org/0000-0001-7978-428X)
- Adarsh Barwad (ORCID: https://orcid.org/0000-0002-4805-3342)
- Venkatesan Sampath Kumar (ORCID: https://orcid.org/0000-0001-7457-4080)
- Love Kapoor (ORCID: https://orcid.org/0000-0002-8280-7822)
- Shah Alam Khan (ORCID: https://orcid.org/0000-0001-9205-9082)
- Vivek Kumar (ORCID: https://orcid.org/0000-0002-5975-9420)
- Archana Sasi (ORCID: https://orcid.org/0000-0002-7095-6740)
- Prabhat Gautam Roy (ORCID: https://orcid.org/0009-0004-3802-3432)
Institutions
- All India Institute of Medical Sciences Raipur (IN)
- All India Institute of Medical Sciences Bhopal (IN)
- DR. B.R.A. Institute Rotary Cancer Hospital (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Journal of bone oncology
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.jbo.2024.100651
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.42