CAVIN2 attenuates ventilator-induced lung injury in rats by MAPK/ERK1/2 signaling pathway
CAVIN2 can bind to ERK1/2 and inhibit the activation of MAPK/ERK1/2 signaling pathway to reduce inflammatory response and autophagy in VILI, thereby reducing lung injury. Therefore, CAVIN2 may be a potential intervention target to provide a new strategy for the treatment of VILI.
Authors
- Wenqu Liu
- Rui Yang (ORCID: https://orcid.org/0000-0002-6983-4762)
- Siyu Lian
- Xianming Zhang (ORCID: https://orcid.org/0000-0002-4653-2630)
- Chunyu Li (ORCID: https://orcid.org/0000-0003-1811-9811)
- Qian Zhu (ORCID: https://orcid.org/0009-0002-5685-4809)
- Ke Wu (ORCID: https://orcid.org/0009-0006-9925-3834)
- Jiayi Zhang (ORCID: https://orcid.org/0009-0007-7970-1967)
- Jun Lv
- Li Wang (ORCID: https://orcid.org/0000-0002-0496-9500)
Institutions
- Guiyang Medical University (CN)
- Anshun University (CN)
- Jinan Maternity And Care Hospital (CN)
- Jinan Central Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- The First People's Hospital of Guiyang (CN)
- Jinan Infectious Disease Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.intimp.2024.113669
- Citations
- 6
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- National Natural Science Foundation of China
- Guizhou Science and Technology Department
- Guizhou Medical University