Decreased mitochondrial transcription factor A and mitochondrial DNA copy number promote cyclin-dependent kinase inhibitor 1A expression and reduce tumorigenic properties of colorectal cancer cells
Our results suggest that TFAM-induced changes of the mitochondrial genome lead to upregulated CDKN1A/p21 expression in colorectal cancer cells identifying p21 as a new possible linker between mitochondria and nucleus.
Authors
- Katrin E. Tagscherer (ORCID: https://orcid.org/0000-0002-0657-6399)
- Wilfried Roth (ORCID: https://orcid.org/0000-0002-4847-9693)
- Hagen Roland Witzel
- Nils Hartmann (ORCID: https://orcid.org/0000-0001-6847-5705)
- Michael Kloth
- Monika Hartmann (ORCID: https://orcid.org/0000-0001-6074-6961)
- Jessika Buchwaldt
- Tania Fritsch
Institutions
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1007/s12672-024-01538-4
- Citations
- 3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Universitätsmedizin der Johannes Gutenberg-Universität Mainz