Down-regulation of TAGLN2 associated with the development of preeclampsia by effecting the Rap1 signaling pathway
Our results confirm that down-regulation of TAGLN2 in HTR-8/SVneo cells leads to the decreased Rap1A expression and suppresses trophoblast cell proliferation and migration by inhibiting Rap1 signaling pathway. Meanwhile, Rap1A down-regulation impede both the proliferation and migration of HTR8/SVneo cells. These findings concluded that down-regulation of TAGLN2 may be implicated in the development of preeclampsia through its effect on the Rap1 signaling pathway.
Authors
- Jinli Lyu
- Ping Liu (ORCID: https://orcid.org/0000-0003-4694-1984)
- Yuzhen Ding
- Xiu‐Qing Li (ORCID: https://orcid.org/0000-0002-7308-0596)
- Yiheng Liang (ORCID: https://orcid.org/0000-0003-3259-2365)
- Peng Zhao (ORCID: https://orcid.org/0000-0002-9296-5293)
- Xiaowei Zhang (ORCID: https://orcid.org/0000-0002-2446-7487)
- Xinyang Liu (ORCID: https://orcid.org/0000-0001-8651-4616)
- Chun‐Feng Liu (ORCID: https://orcid.org/0000-0002-8364-0219)
- Shilin Zhong (ORCID: https://orcid.org/0000-0002-0295-1294)
- Kaidong Ma
- Ping Yang (ORCID: https://orcid.org/0000-0002-0321-1132)
- Qiaoli Feng
- Shangrong Fan
- Liting Huang
Institutions
- Hong Kong University of Science and Technology (HK)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
Publication Details
- Journal
- Placenta
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1016/j.placenta.2024.11.009
- Citations
- 4
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33