Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study

While adherence to guidelines for the choice of empirical antibiotic therapy was relatively high, adherence to guidelines for therapy duration was significantly lower, largely due to extended post-discharge antibiotic treatment. Our findings suggest that publishing updated guidelines alone is insufficient to change clinical practice. Targeted stewardship interventions, particularly those addressing discharge practices, are essential. Future research should compare adherence rates across institutions to identify factors contributing to higher adherence and develop standardized benchmarks for optimal antibiotic stewardship. Trial registration NCT04660084.

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Publication Details

Journal
Antimicrobial Resistance and Infection Control
Published
2024-11-23
DOI
https://doi.org/10.1186/s13756-024-01494-2
Citations
4
Primary Topic
Pneumonia and Respiratory Infections
Type
article
Field-Weighted Citation Impact
1.55

Funders

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article

Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study

Dagfinn Lunde Markussen, Siri Tandberg Knoop, Sondre Serigstad, Christian Ritz et al.
4 citations
Antimicrobial Resistance and Infection Control
Pneumonia and Respiratory Infections
1.55
article

Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study

Dagfinn Lunde Markussen, Siri Tandberg Knoop, Sondre Serigstad, Christian Ritz, Cornelis H. van Werkhoven, Rune Bjørneklett, Jannicke Slettli Wathne, Elling Ulvestad, Harleen M. S. Grewal, Synne Jenum
article en
4 citations

Abstract

While adherence to guidelines for the choice of empirical antibiotic therapy was relatively high, adherence to guidelines for therapy duration was significantly lower, largely due to extended post-discharge antibiotic treatment. Our findings suggest that publishing updated guidelines alone is insufficient to change clinical practice. Targeted stewardship interventions, particularly those addressing discharge practices, are essential. Future research should compare adherence rates across institutions to identify factors contributing to higher adherence and develop standardized benchmarks for optimal antibiotic stewardship. Trial registration NCT04660084.

Antimicrobial Resistance and Infection ControlVol. 13(1)
Oslo University Hospital (NO), University of Southern Denmark (DK), Utrecht University (NL), Haukeland University Hospital (NO), University Medical Center Utrecht (NL), University of Bergen (NO)
Trond Mohn stiftelse, Universitetet i Bergen, Norges Forskningsråd
Good health and well-being
Openalex Percentile: Top 15%
Pneumonia and Respiratory Infections
1.55
DOIOpen Access PDFOpenAlex
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