Xibining inhibition of the PI3K-AKT pathway reduces M1 macrophage polarization to ameliorate KOA synovial inflammation and nociceptive sensitization
XBN improve KOA nociceptive sensitization by modulating the PI3K/Akt signaling pathway, attenuating the level of synovial inflammation and inhibiting M1-type macrophage polarization in synovial and DRG tissues in KOA mice.
Authors
- Peimin Wang (ORCID: https://orcid.org/0000-0002-5454-878X)
- Songjiang Yin
- Zeling Huang (ORCID: https://orcid.org/0000-0002-2014-9844)
- Zaishi Zhu
- Xiaochen Li (ORCID: https://orcid.org/0000-0003-4674-9343)
- Li Zhang (ORCID: https://orcid.org/0000-0002-6862-0041)
- Junfeng Kang (ORCID: https://orcid.org/0000-0002-8477-7049)
- Houyu Fu
- Wei Mei (ORCID: https://orcid.org/0009-0008-0390-0190)
- Lishi Jie (ORCID: https://orcid.org/0000-0003-4158-1844)
- Peng Wu (ORCID: https://orcid.org/0000-0003-1358-874X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Jiangsu Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.phymed.2024.156281
- Citations
- 12
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.89