DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis
DsbA-L exhibited a significant profibrotic effect in lung epithelial cells and mice, which increased the levels of AKT1 and NLRP3 to activate the TGF-β1/SMAD3 pathway and M2 macrophage polarization. These findings could shed light on new clues for comprehension and treatment of PF.
Authors
- Hongzuo Chen
- Bei Qing (ORCID: https://orcid.org/0000-0003-4740-2923)
- Ying Chen
- Linguo Gu
- Zhenkun Xia (ORCID: https://orcid.org/0000-0001-8923-0504)
- Juan Wang (ORCID: https://orcid.org/0000-0001-8724-9850)
- Yunchang Yuan
- Zhenglian Ge
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1186/s10020-024-00983-9
- Citations
- 13
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China