Fatal disseminated congenital cytomegalovirus infection in a twin preterm neonate: A clinical-pathological diagnosis

We report on a rare case of congenital cytomegalovirus (CMV) in a dichorionic diamniotic twins. The uniqueness of one of the twins having a fatal disseminated CMV infection with the other twin being normal has been discussed. In cases with no antenatal diagnosis, the role of post-clinical-pathological correlation using fetal autopsy has been described with fetal autopsy images (gross and microscopy). The possible immunological basis for the selective affection of one twin and a review of literature on similar cases have also been done.