TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure
These findings highlight a link between the neuroinflammatory processes triggered by the gut microbiota components LPS and the dysregulation of the reward system during HFD-induced obesity through the TLR4 pathway, thus paving the way for future therapeutic approaches.
Authors
- Cécile Fayt
- Serge Luquet (ORCID: https://orcid.org/0000-0001-8668-6645)
- Amandine Everard (ORCID: https://orcid.org/0000-0001-8925-8144)
- Patrice D. Cani (ORCID: https://orcid.org/0000-0003-2040-2448)
- Sabrina J. P. Huwart (ORCID: https://orcid.org/0000-0002-7709-1268)
- Giuseppe Gangarossa (ORCID: https://orcid.org/0000-0001-9045-2139)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut Universitaire de France (FR)
- Université Paris Cité (FR)
- Unit of Functional and Adaptive Biology (FR)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- UCLouvain (BE)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1186/s12974-024-03297-z
- Citations
- 17
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.68
Funders
- Université Catholique de Louvain
- Fonds De La Recherche Scientifique - FNRS