Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort
Faster DunedinPACE is associated with preclinical cognitive aging.Higher baseline cognition was protective of DunedinPACE-associated cognitive decline.The DunedinPACE association with cognitive decline explained a fourth of dementia risk.
Authors
- Calen P. Ryan (ORCID: https://orcid.org/0000-0002-0550-7949)
- Allison E. Aiello (ORCID: https://orcid.org/0000-0001-7029-2537)
- Micah J. Savin (ORCID: https://orcid.org/0000-0002-1534-0839)
- Avshalom Caspi (ORCID: https://orcid.org/0000-0003-0082-4600)
- Yaakov Stern (ORCID: https://orcid.org/0000-0001-7542-3241)
- Daniel W. Belsky (ORCID: https://orcid.org/0000-0001-5463-2212)
- Stephanie Assuras
- Heming Pei
- Baoyi Shi (ORCID: https://orcid.org/0000-0001-7524-9351)
- Terrie E. Moffitt (ORCID: https://orcid.org/0000-0002-8589-6760)
- Karen Sugden (ORCID: https://orcid.org/0000-0002-4076-5927)
- Linda Valeri (ORCID: https://orcid.org/0000-0003-0664-1194)
- Peter A. Muenning
- Haoyang Wang (ORCID: https://orcid.org/0009-0009-8086-7010)
Institutions
- Duke University (US)
- King's College London (GB)
- University of Oslo (NO)
- Columbia University Irving Medical Center (US)
- Trinity College (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70038
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 3.47
Funders
- Canadian Institute for Advanced Research
- National Institute on Aging