A critical reflection of radiotherapy on osseous free flaps in mandibular segmental resection and immediate reconstruction in locally advanced oral squamous cell carcinoma: A cohort study
PORT is associated with higher flap complications and need for secondary surgeries in advanced stage OSCC. Given a recurrence rate of zero inside the flap without PORT and the improbability of recurrence within healthy transplanted tissue, the usefulness of applying high radiation doses to this vulnerable tissue is questioned. Further refinements of RT planning should be evaluated and tested in a RCT trial.
Authors
- Claudius Steffen (ORCID: https://orcid.org/0000-0003-4221-4878)
- Christian Doll (ORCID: https://orcid.org/0000-0002-0439-759X)
- Friedrich Mrosk (ORCID: https://orcid.org/0000-0002-6956-3843)
- Marcus Beck (ORCID: https://orcid.org/0000-0003-1940-2571)
- Carsten Rendenbach (ORCID: https://orcid.org/0000-0002-9565-7640)
- Kilian Kreutzer (ORCID: https://orcid.org/0000-0003-0581-4137)
- Steffen Koerdt (ORCID: https://orcid.org/0000-0002-8679-8775)
- Max Heiland (ORCID: https://orcid.org/0000-0002-4987-2913)
- Philipp Lampert (ORCID: https://orcid.org/0009-0005-9392-728X)
- Jakob Fenske (ORCID: https://orcid.org/0009-0000-3453-3903)
- Eirini Nikolaidou
Institutions
- Humboldt-Universität zu Berlin (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.radonc.2024.110652
- Citations
- 10
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.80