Haemodynamics in Left Ventricular Remodelling using Cardiovascular Lumped-Parameter Model

Left ventricular remodelling is one of the complications of myocardial infarction.It causes the ventricle to lose contractility and to become dilate, thus changing the cardiac haemodynamics.In this study, the haemodynamic changes in left ventricular remodelling are investigated using the cardiovascular lumped-parameter model.The model simplifies blood circulation and cardiac function using electrical components such as resistor, capacitor, inductor, and diode, which represent the vessels resistance, vessels compliance, blood inertia, and heart valve, respectively.To simulate ventricular remodelling, the active and passive elastances of the left ventricle are varied by increasing and decreasing them by 10 times than the baseline values.Decreasing the active elastance reduces LV contractility, like in the case of a heart failure.Meanwhile, increasing the passive elastance makes the LV stiffer, like in the case of ventricular hypertrophy.The model eases the analysis of left ventricular remodelling without requiring complex model but will require further validation using real patients data.