Stage-Specific Tumoral Gene Expression Profiles of Black and White Patients with Colon Cancer
Significant transcriptional differences exist in CC between Black and white patients changing dynamically across disease stages, and involving genes with broad functions. Key findings include IL-17 pathway downregulation in Black patients with localized disease and a five-gene signature consistent across all stages. These findings may explain aspects of racial disparities in CC, emphasizing the need for race-specific research and treatment strategies.
Authors
- Mohamad El Moheb (ORCID: https://orcid.org/0000-0002-1897-2145)
- Allan Tsung
- Samantha M. Ruff (ORCID: https://orcid.org/0000-0001-5275-6705)
- Russell Gardner Witt (ORCID: https://orcid.org/0000-0003-3747-8633)
- Koen Putman (ORCID: https://orcid.org/0000-0002-7235-3759)
- Chengli Shen (ORCID: https://orcid.org/0000-0003-4731-2872)
- Hongji Zhang (ORCID: https://orcid.org/0000-0002-7704-4365)
- Susan Kim (ORCID: https://orcid.org/0000-0002-0924-8964)
Institutions
- University of Virginia (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1245/s10434-024-16550-9
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.85