The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions
Interaction with the hyaluronan receptor CD44 modulates both the constitutive activity of 5-HT7R as well as its agonist-mediated signaling. Heteromerization also results in the transactivation of 5-HT7R-mediated signaling via CD44 ligand.
Authors
- Saskia Borsdorf (ORCID: https://orcid.org/0000-0002-9348-9583)
- Evgeni G. Ponimaskin (ORCID: https://orcid.org/0000-0002-4570-5130)
- André Zeug (ORCID: https://orcid.org/0000-0001-9858-5841)
- Josephine Labus (ORCID: https://orcid.org/0000-0002-5064-6382)
- Еlena V. Mitroshina (ORCID: https://orcid.org/0000-0003-1703-2618)
- Maria V. Vedunova (ORCID: https://orcid.org/0000-0001-9759-6477)
- Supriya A. Gaitonde
- Michael C. Wehr (ORCID: https://orcid.org/0000-0003-1770-8323)
- Yuxin Wu (ORCID: https://orcid.org/0000-0002-1586-6160)
- Michel Bouvier (ORCID: https://orcid.org/0000-0003-1128-0100)
Institutions
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- Institute for Research in Immunology and Cancer (CA)
- Max Planck Institute of Biochemistry (DE)
- Université de Montréal (CA)
- N. I. Lobachevsky State University of Nizhny Novgorod (RU)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1186/s12964-024-01931-0
- Citations
- 4
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.94