Spatial dissection of tumour microenvironments in gastric cancers reveals the immunosuppressive crosstalk between <i>CCL2+</i> fibroblasts and <i>STAT3</i> -activated macrophages
GC spatial transcriptomes revealed functional cellular crosstalk involving multiple cell types among which the interaction between <i>CCL2+</i> fibroblasts and <i>STAT3</i>-activated macrophages plays roles in establishing immune-suppressive GC TME with potential clinical relevance.
Authors
- In Hye Song (ORCID: https://orcid.org/0000-0001-6325-3548)
- Dagyeong Lee (ORCID: https://orcid.org/0000-0002-6542-6526)
- Hoon Hur (ORCID: https://orcid.org/0000-0002-5435-5363)
- Sung Hak Lee (ORCID: https://orcid.org/0000-0003-1020-5838)
- Jun Yong Choi (ORCID: https://orcid.org/0000-0002-2775-3315)
- In‐Hye Ham (ORCID: https://orcid.org/0000-0002-3168-5597)
- Youngbeen Moon (ORCID: https://orcid.org/0009-0008-9046-076X)
- Hyeseong Lee (ORCID: https://orcid.org/0000-0002-7137-8874)
- Daeun Ryu (ORCID: https://orcid.org/0000-0002-2666-2104)
- Sunmin Kim (ORCID: https://orcid.org/0000-0003-0077-1924)
- Tae‐Min Kim (ORCID: https://orcid.org/0000-0002-7993-9701)
- Kyo Young Song (ORCID: https://orcid.org/0000-0002-5840-1638)
- Hye Jeong Oh
- Dong-Jin Han
- Seo-Yeong Lee
- Seungho Lee (ORCID: https://orcid.org/0000-0003-2316-6073)
Institutions
- Ulsan College (KR)
- Yonsei University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Ajou University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Gut
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1136/gutjnl-2024-332901
- Citations
- 31
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.46
Funders
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea