A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naïve first episode psychosis patients
We report a progressive loss of hippocampal subfield volumes over a period of 16 weeks after initiation of treatment, suggestive of early progression in neuropathology. Our results do not suggest a role for glutamate as a driving factor. This study underscores the need to further research the mechanism(s) underlying this phenomenon as it has implications for early intervention to preserve cognitive decline in FEP participants.
Authors
- Stacey S. Cofield (ORCID: https://orcid.org/0000-0002-1104-3087)
- Adrienne C. Lahti (ORCID: https://orcid.org/0000-0002-5565-7662)
- William P. Armstrong
- Eric Nelson (ORCID: https://orcid.org/0000-0002-4084-8570)
- Jose O. Maximo (ORCID: https://orcid.org/0000-0002-7204-8623)
- Nina V. Kraguljac (ORCID: https://orcid.org/0000-0003-2567-4098)
- Adil Bashir (ORCID: https://orcid.org/0000-0003-2030-9294)
Institutions
- University of Alabama at Birmingham (US)
- The Ohio State University (US)
- Auburn University (US)
Publication Details
- Journal
- Molecular Psychiatry
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1038/s41380-024-02812-1
- Citations
- 7
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- National Institutes of Health
- National Institute of Mental Health
- National Center for Advancing Translational Sciences