Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR
Positron emission tomography-magnetic resonance (PET-MR) analysis of the piriform cortex sheds light on its role as a potential early region affected by neurodegenerative disorders underlying olfactory dysfunction.Uptake of tau tracer was elevated in the piriform cortex in Alzheimer's disease (AD) and mild cognitive impairment (MCI) but not in Parkinson's disease (PD).Memory performance was worse with greater piriform uptake.
Authors
- Michael Zeineh (ORCID: https://orcid.org/0000-0002-6940-9096)
- Marios Georgiadis (ORCID: https://orcid.org/0000-0003-0733-4559)
- Mahta Karimpoor (ORCID: https://orcid.org/0000-0001-8025-6230)
- America Romero
- Anthony D. Wagner (ORCID: https://orcid.org/0000-0003-0624-4543)
- Guido Davidzon (ORCID: https://orcid.org/0000-0001-5579-6825)
- Jarrett Rosenberg (ORCID: https://orcid.org/0000-0003-2706-3290)
- Maya Yutsis
- Kathleen L. Poston (ORCID: https://orcid.org/0000-0003-3424-7143)
- Mackenzie Carlson (ORCID: https://orcid.org/0000-0002-0857-3116)
- Greg Zaharchuk (ORCID: https://orcid.org/0000-0001-5781-8848)
- Hossein Moein Taghavi (ORCID: https://orcid.org/0000-0002-8585-1634)
- Eric K. van Staalduinen (ORCID: https://orcid.org/0000-0001-9786-2712)
- Alexandra N. Trelle (ORCID: https://orcid.org/0000-0003-2837-8753)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Christina B. Young (ORCID: https://orcid.org/0000-0001-9535-2137)
- Victor W. Henderson (ORCID: https://orcid.org/0000-0003-1198-9240)
- Hillary Vossler
- Samantha Leventis
Institutions
- Neurosciences Institute (US)
- Stanford Health Care (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70040
- Citations
- 4
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- Alzheimer's Association
- National Institutes of Health
- Wu Tsai Neurosciences Institute, Stanford University