Input of exome sequencing in early‐onset cerebral amyloid angiopathy
The genetic component of cerebral amyloid angiopathy (CAA) remains understudied.Rare differential diagnoses such as CADASIL should be considered, even in cases of cerebral hemorrhage.Our study suggests shared genetic factors between AD and CAA, beyond the <i>APOE</i> gene.Rare variants in <i>SORL1, TREM2</i>, <i>ABCA7, ABCA1</i> and <i>ATP8B4</i> might be susceptibility factors in early-onset CAA.
Authors
- Camille Charbonnier (ORCID: https://orcid.org/0000-0003-1172-0196)
- David Wallon (ORCID: https://orcid.org/0000-0002-2634-7198)
- Elisabeth Tournier‐Lasserve (ORCID: https://orcid.org/0000-0002-3039-1677)
- Lou Grangeon (ORCID: https://orcid.org/0000-0002-8458-7683)
- Gaël Nicolas (ORCID: https://orcid.org/0000-0001-9391-7800)
- Robert Olaso
- Aline Zaréa (ORCID: https://orcid.org/0000-0002-8215-9140)
- Stéphane Rousseau
- Jean‐François Deleuze
- Anne Boland
- Olivier Quenez
- Anne Richard
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Centre National de Recherche en Génomique Humaine (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- CEA Paris-Saclay (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70027
- Citations
- 2
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Agence Nationale de la Recherche
- Université de Rouen