Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population‐based data
Healthy and AD olfactory cells respond differently to DE exposure. AD cells are highly susceptible to DE exposure. The NRF2 oxidative stress response is highly activated upon air pollution exposure. DE-exposed AD cells activate the unfolded protein response pathway. Key findings are also confirmed in a population-based study.
Authors
- Rosalba Giugno (ORCID: https://orcid.org/0000-0001-9843-7638)
- Tereza Červená (ORCID: https://orcid.org/0000-0001-9248-2761)
- Michal Šíma (ORCID: https://orcid.org/0000-0001-6927-8615)
- Pasi Jalava (ORCID: https://orcid.org/0000-0003-2753-0397)
- Katja M. Kanninen (ORCID: https://orcid.org/0000-0002-6717-8589)
- Liudmila Saveleva (ORCID: https://orcid.org/0000-0002-4467-7131)
- Elina Penttilä (ORCID: https://orcid.org/0000-0002-4818-2734)
- Michal Vojtíšek-Lom (ORCID: https://orcid.org/0000-0002-8807-0921)
- Kristýna Vrbová
- Heikki Löppönen (ORCID: https://orcid.org/0000-0002-2002-5358)
- Sweelin Chew (ORCID: https://orcid.org/0000-0001-9750-160X)
- Zuzana Šímová (ORCID: https://orcid.org/0009-0002-4993-0607)
- Jan Topinka (ORCID: https://orcid.org/0000-0001-6860-7253)
- Claudia Mengoni (ORCID: https://orcid.org/0000-0001-9629-2930)
- Tarja Malm
- Anne M. Koivisto (ORCID: https://orcid.org/0000-0002-0388-0379)
- Muhammad Shahbaz (ORCID: https://orcid.org/0000-0001-5031-8218)
- Tosca O. E. de Crom (ORCID: https://orcid.org/0000-0001-6869-043X)
- Jitka Sikorová (ORCID: https://orcid.org/0000-0002-6143-0229)
- Zdeněk Krejčík (ORCID: https://orcid.org/0000-0002-8321-2644)
- Pavel Rössner (ORCID: https://orcid.org/0000-0001-6921-5446)
- Laura Mussalo (ORCID: https://orcid.org/0000-0002-9765-2528)
- Mariia Ivanova
- M. Arfan Ikram
Institutions
- University of Verona (IT)
- University of Helsinki (FI)
- Technical University of Liberec (CZ)
- University of Eastern Finland (FI)
- Helsinki University Hospital (FI)
- Erasmus MC (NL)
- Kuopio University Hospital (FI)
- Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
- Czech Technical University in Prague (CZ)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1002/alz.14347
- Citations
- 6
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 1.89
Funders
- Itä-Suomen Yliopisto
- EU Joint Programme – Neurodegenerative Disease Research
- European Commission
- Grantová Agentura České Republiky
- ZonMw
- Suomen Kulttuurirahasto
- Vereniging Trustfonds Erasmus Universiteit Rotterdam
- Pohjois-Savon Rahasto