Performance of plasma p‐tau217 and NfL in an unselected memory clinic setting
Phosphorylated tau-2017 (p-tau217) can detect Alzheimer's disease (AD) across the clinical continuum.Neurofilament light (NfL) can differentiate frontotemporal dementia (FTD) from other diagnoses (AD dementia, dementia with Lewy bodies [DLB], and Psychiatry).p-Tau217 may detect AD co-pathology in other diseases or dementia types (e.g., DLB).p-Tau217 and NfL show potential for clinical implementation.
Authors
- Argonde C. van Harten (ORCID: https://orcid.org/0000-0002-1477-8724)
- Afina W. Lemstra (ORCID: https://orcid.org/0000-0002-8933-3260)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Thomas Claessen
- Rebecca Z. Rousset (ORCID: https://orcid.org/0000-0001-9355-7286)
- Anouk den Braber (ORCID: https://orcid.org/0000-0002-3377-2627)
- Inge M.W. Verberk (ORCID: https://orcid.org/0000-0003-0341-7445)
- Andreas Jeromin
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
Institutions
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70003
- Citations
- 11
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- National Multiple Sclerosis Society
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- EU Joint Programme – Neurodegenerative Disease Research
- Health~Holland
- Multiple Sclerosis Society
- European Commission
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Alzheimer Nederland