High tumor glucocorticoid receptor expression in early-stage, triple-negative breast cancer is associated with increased T-regulatory cell infiltration
These data support the hypothesis that in early-stage TNBC, high GR expression is significantly associated with infiltration of immunosuppressive regulatory T cells, suggesting a tumor-intrinsic role in shaping the immunosuppressive immune cell milieu. Furthermore, suppression of GR activity may regulate the tumor immune microenvironment and improve long-term outcomes in GR-high TNBC.
Authors
- Rita Nanda (ORCID: https://orcid.org/0000-0001-5248-0876)
- Suzanne Daniela Conzen (ORCID: https://orcid.org/0000-0003-1750-5868)
- Poornima Saha (ORCID: https://orcid.org/0009-0005-6609-7188)
- Anna Biernacka (ORCID: https://orcid.org/0000-0002-0080-5947)
- Marie Dreyer (ORCID: https://orcid.org/0009-0001-0827-057X)
- Deniz Nesli Dolcen (ORCID: https://orcid.org/0000-0003-2441-7313)
- Theodore Karrison (ORCID: https://orcid.org/0009-0009-8641-5111)
- Christine Y. Shiang
- Margarite D. Matossian (ORCID: https://orcid.org/0000-0002-9527-1043)
- Ken Hatogai (ORCID: https://orcid.org/0000-0001-7888-7965)
- Nan Chen (ORCID: https://orcid.org/0000-0001-9938-9957)
- Randy F. Sweis (ORCID: https://orcid.org/0000-0002-0497-9637)
- Katie Hall (ORCID: https://orcid.org/0000-0003-4217-7245)
Institutions
- Chicago Department of Public Health (US)
- University of Chicago (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1007/s10549-024-07515-3
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Cancer Prevention and Research Institute of Texas
- University of Chicago
- National Institutes of Health