Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study
We found evidence of a weak positive association between LDL-C and CRC that did not appear to be explained by potential pleiotropic pathways such as via HDL-C, triglycerides, BMI, or diabetes.
Authors
- Themistocles L. Assimes (ORCID: https://orcid.org/0000-0003-2349-0009)
- Konstantinos K. Tsilidis (ORCID: https://orcid.org/0000-0002-8452-8472)
- Wei Zheng (ORCID: https://orcid.org/0000-0003-3655-0429)
- Verena Zuber (ORCID: https://orcid.org/0000-0001-9827-1877)
- Sébastien Küry (ORCID: https://orcid.org/0000-0001-5497-0465)
- Christopher I. Li (ORCID: https://orcid.org/0000-0003-1543-0743)
- Michael O. Woods (ORCID: https://orcid.org/0000-0001-8180-418X)
- Minta Thomas (ORCID: https://orcid.org/0000-0001-9337-7015)
- Ulrike Peters (ORCID: https://orcid.org/0000-0001-5666-9318)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Neil Murphy (ORCID: https://orcid.org/0000-0003-3347-8249)
- Brigid Mary Lynch (ORCID: https://orcid.org/0000-0001-8060-547X)
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Stephen B. Gruber (ORCID: https://orcid.org/0000-0001-8656-7822)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Luís Bujanda (ORCID: https://orcid.org/0000-0002-4353-9968)
- Emmanouil Bouras (ORCID: https://orcid.org/0000-0003-1489-5506)
- Wing Ching Chan (ORCID: https://orcid.org/0000-0001-7090-6551)
- Wanqing Wen (ORCID: https://orcid.org/0000-0002-3004-5168)
- Conghui Qu (ORCID: https://orcid.org/0000-0003-1927-6245)
- Lili Liu (ORCID: https://orcid.org/0000-0002-2622-9669)
- Jirong Long (ORCID: https://orcid.org/0000-0002-7433-9766)
- Emily White
Institutions
- City Of Hope National Medical Center (US)
- Memorial University of Newfoundland (CA)
- The University of Melbourne (AU)
- University of the Basque Country (ES)
- German Cancer Research Center (DE)
- University of Ioannina (GR)
- Cancer Council Victoria (AU)
- University of Washington (US)
- VA Palo Alto Health Care System (US)
- Heidelberg University (DE)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Biogipuzkoa Health Research Institute (ES)
- National Center for Tumor Diseases (DE)
- UK Dementia Research Institute (GB)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Génétique Médicale & Génomique Fonctionelle (FR)
- Centre international de recherche sur le cancer (FR)
- MRC Centre for Environment and Health
- Imperial College London (GB)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
- Nantes Université (FR)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1038/s41416-024-02900-7
- Citations
- 9
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- World Cancer Research Fund International
- Cancer Research UK
- Wereld Kanker Onderzoek Fonds
- Medical Research Council
- World Cancer Research Fund