Association of environmental pollutants with asthma and allergy, and the mediating role of oxidative stress and immune markers in adolescents
This study found associations between phthalates, MnBP and MBzP, and elevated FeNO, which appeared to be mediated by eosinophil count. 8-OHdG plays a significant mediating role in the association between 2,4-D, TCPY, and 1-NAP with rhinitis, while their direct effects remain non-significant. Use of inflammatory and oxidative stress markers can enhance the understanding of inflammatory processes in asthma and allergic diseases due to environmental pollutants.
Authors
- Eva Govarts (ORCID: https://orcid.org/0000-0002-6075-4862)
- Hamid Yimam Hassen (ORCID: https://orcid.org/0000-0001-6485-4193)
- Lützen Portengen (ORCID: https://orcid.org/0000-0003-1537-1843)
- Gudrun Koppen (ORCID: https://orcid.org/0000-0001-6014-7803)
- Adrian Covaci (ORCID: https://orcid.org/0000-0003-0527-1136)
- Sylvie Rémy (ORCID: https://orcid.org/0000-0003-0322-9620)
- Liesbeth M. Bruckers (ORCID: https://orcid.org/0000-0002-6978-3002)
- Greet E. R. Schoeters (ORCID: https://orcid.org/0000-0002-6556-4814)
- Nina Iszatt (ORCID: https://orcid.org/0000-0002-8977-156X)
- B. Cox (ORCID: https://orcid.org/0000-0001-9824-6276)
- Veerle J. Verheyen (ORCID: https://orcid.org/0000-0002-5262-5665)
- Stefaan De Henauw
- Elly Den Hond
Institutions
- Norwegian Institute of Public Health (NO)
- University of Antwerp (BE)
- Utrecht University (NL)
- Ghent University Hospital (BE)
- Ghent University (BE)
- Flemish Institute for Technological Research (BE)
- Hasselt University (BE)
Publication Details
- Journal
- Environmental Research
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1016/j.envres.2024.120445
- Citations
- 12
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 3.78