Xiaoai Jiedu recipe reduces cell survival and induces apoptosis in hepatocellular carcinoma by stimulating autophagy via the AKT/mTOR pathway
These studies show that XJR activates autophagy in both cellular and animal models to induce apoptosis and decrease HCC cell proliferation, as shown by network pharmacology and verification assays. Further, these findings provide experimental evidence that the anti-tumor activity of XJR involves autophagy stimulation.
Authors
- Hengzhou Zhu
- Ji Yi (ORCID: https://orcid.org/0000-0001-6583-7192)
- Xi Chen (ORCID: https://orcid.org/0000-0003-1412-5886)
- Li Li (ORCID: https://orcid.org/0000-0003-2247-5720)
- Liu Li (ORCID: https://orcid.org/0000-0003-2376-8162)
- Wenting Li (ORCID: https://orcid.org/0000-0001-5288-8310)
- Wenyue Zhao
- Yanxia Ma (ORCID: https://orcid.org/0000-0002-7589-2707)
- Jiege Huo (ORCID: https://orcid.org/0000-0002-7170-6225)
- Qingfeng Li (ORCID: https://orcid.org/0000-0002-0314-0864)
- Mianhua Wu (ORCID: https://orcid.org/0000-0001-7626-6874)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Wuxi Taihu Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1016/j.jep.2024.119135
- Citations
- 6
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.32