Qingke Pingchuan granules alleviate airway inflammation in COPD exacerbation by inhibiting neutrophil extracellular traps in mice
These findings suggest that QKPC granules alleviate airway inflammation in ECOPD, potentially through inhibition of pulmonary NET formation via the NOX2/p47phox-ROS pathway, underscoring their potential therapeutic application for ECOPD management in clinical settings.
Authors
- Yu Wu (ORCID: https://orcid.org/0000-0002-8777-7191)
- Yan Xi (ORCID: https://orcid.org/0000-0002-1829-6554)
- Mengxin Cheng
- Yutian Zhang (ORCID: https://orcid.org/0000-0003-0512-9025)
- Jun Chen (ORCID: https://orcid.org/0000-0002-1571-428X)
- Tao Wang (ORCID: https://orcid.org/0000-0001-9607-8272)
- Fuqiang Wen (ORCID: https://orcid.org/0000-0001-6205-4758)
- Zijian Zeng
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1016/j.phymed.2024.156283
- Citations
- 15
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.61
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University