Pixel-super-resolved lensless on-chip microscopy using a color image sensor

We report a wavelength-scanning-based lensless on-chip microscope using a color CMOS sensor and a matching modified phase retrieval algorithm for pixel super-resolution. Without physically removing the Bayer color filter array positioned on the sensor chip, we demonstrate quantitative phase imaging with a lateral resolution of 615 nm over a wide field-of-view of 51.88 mm<sup>2</sup> by exploiting the green-channel data from a set of low-resolution holograms captured at various wavelengths. The resulting spatial bandwidth product is 274.3 Megapixels, over 20 times higher than a conventional optical microscope.

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Publication Details

Published
2024-11-23
DOI
https://doi.org/10.1117/12.3035920
Primary Topic
Advanced Fluorescence Microscopy Techniques
Type
article
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article

Pixel-super-resolved lensless on-chip microscopy using a color image sensor

Chao Zuo, Yang Chen, Xuejuan Wu
Advanced Fluorescence Microscopy Techniques
article

Pixel-super-resolved lensless on-chip microscopy using a color image sensor

Chao Zuo, Yang Chen, Xuejuan Wu
article en

Abstract

We report a wavelength-scanning-based lensless on-chip microscope using a color CMOS sensor and a matching modified phase retrieval algorithm for pixel super-resolution. Without physically removing the Bayer color filter array positioned on the sensor chip, we demonstrate quantitative phase imaging with a lateral resolution of 615 nm over a wide field-of-view of 51.88 mm<sup>2</sup> by exploiting the green-channel data from a set of low-resolution holograms captured at various wavelengths. The resulting spatial bandwidth product is 274.3 Megapixels, over 20 times higher than a conventional optical microscope.

Nanjing University of Science and Technology (CN)
Affordable and clean energy
Openalex Percentile: Top 87%
Advanced Fluorescence Microscopy Techniques
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