Exercise-induced anxiety impairs local and systemic inflammatory response and glucose metabolism in C57BL/6J mice
A protocol of exercise that induces anxiety is associated with a neuroimmunoendocrine dysregulation affecting the feedback between the inflammatory and the stress responses, together with detrimental metabolic effects in glucose modulation. Systemic inflammatory alterations are accompanied by detrimental inflammatory responses in tissue macrophage populations. Altogether, these results show that exercise associated with anxiety, stress, pro-inflammatory responses, and hyperglycaemia represents a model of 'dangerous exercise'.
Authors
- María Dolores Hinchado
- Isabel Gálvez (ORCID: https://orcid.org/0000-0002-4294-4507)
- Eduardo Ortega (ORCID: https://orcid.org/0000-0002-7007-7615)
- Leticia Martín-Cordero (ORCID: https://orcid.org/0000-0002-3651-2265)
- Miguel Navarro (ORCID: https://orcid.org/0000-0003-2301-2699)
- Silvia Torres-Piles (ORCID: https://orcid.org/0000-0001-9918-0889)
Institutions
- Government of Extremadura (ES)
- Centro Tecnológico Nacional Agroalimentario Extremadura (ES)
- Hospital Virgen del Puerto (ES)
- Universidad de Extremadura (ES)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1016/j.bbih.2024.100910
- Citations
- 2
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Universidad de Extremadura
- European Regional Development Fund