Patient-derived glioma organoids real time identification of IDH mutation, 1p/19q-codeletion and CDKN2A/B homozygous deletion with differential ion mobility spectrometry
DMS suitability to differentiate IDH-mutated PGOs was thus validated in ex vivo cultured samples, PGOs. Preliminary results regarding 1p/19q codeleted PGOs and CDKN2A/B loss PGOs identification endorse testing in a prospective intraoperative glioma patient cohort. Our results reveal a sample classification set-up that is compatible with real-time intraoperative surgery guidance.
Authors
- Kristiina Nordfors (ORCID: https://orcid.org/0000-0002-3680-4524)
- Juhana Frösén (ORCID: https://orcid.org/0000-0003-4677-950X)
- Ilkka Haapala (ORCID: https://orcid.org/0000-0003-0383-7319)
- Ismaïl Hermelo (ORCID: https://orcid.org/0009-0009-9381-839X)
- Anton Kontunen (ORCID: https://orcid.org/0000-0002-2220-1351)
- Markus Karjalainen (ORCID: https://orcid.org/0000-0003-4592-3661)
- Meri Mäkelä (ORCID: https://orcid.org/0000-0003-0875-8257)
- Matti Nykter (ORCID: https://orcid.org/0000-0001-6956-2843)
- Antti Vehkaoja (ORCID: https://orcid.org/0000-0003-3721-3467)
- Philipp Müller (ORCID: https://orcid.org/0000-0003-4314-7339)
- Dafne Jacome Sanz
- Joonas Haapasalo (ORCID: https://orcid.org/0000-0002-6468-4937)
- Niku Oksala (ORCID: https://orcid.org/0000-0001-5336-3719)
- Antti Roine (ORCID: https://orcid.org/0000-0002-1811-2671)
- Kai Lehtimäki
- Hannu Haapasalo (ORCID: https://orcid.org/0000-0003-4389-7391)
Institutions
- Tampere University of Applied Sciences (FI)
- Tampere University (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Fimlab (Finland) (FI)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1007/s11060-024-04891-0
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- Lasten Syöpäsäätiö Väreen
- Academy of Finland
- Emil Aaltosen Säätiö
- Tays