TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study
This study demonstrates that TIMP1 expression is increased during type 2 diabetic osteoporosis and that TIMP1 promotes ferroptosis in osteoblasts by regulating TFRC. These findings suggest that TIMP1 is a promising novel therapeutic target for type 2 diabetic osteoporosis.
Authors
- Xiaoyun Sheng
- Jinmin Liu (ORCID: https://orcid.org/0000-0002-4907-3273)
- Bin Geng (ORCID: https://orcid.org/0000-0002-1505-3645)
- Rongjin Chen
- Bo Peng (ORCID: https://orcid.org/0000-0003-4183-5939)
- Zhiwei Feng (ORCID: https://orcid.org/0000-0001-6533-8932)
- Jinwen He
- Yayi Xia (ORCID: https://orcid.org/0000-0002-3771-8687)
- Ao Yang (ORCID: https://orcid.org/0000-0003-1105-1498)
- Xingwen Wang (ORCID: https://orcid.org/0000-0003-0480-8835)
- XU Li-hu
- Yaobin Wang (ORCID: https://orcid.org/0009-0001-3311-830X)
- Xiaojun Ren
- Cong Tian
Institutions
- Nexen (Canada) (CA)
- Gansu Research Institute of Chemical Industry (CN)
- Lanzhou University Second Hospital (CN)
- Gansu Institute of Political Science and Law (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1186/s10020-024-01000-9
- Citations
- 9
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- Lanzhou University
- National Natural Science Foundation of China
- Natural Science Foundation of Gansu Province