Study of Serum Uric Acid Level with Severity of Chronic Liver Disease

Background: Chronic liver disease (CLD) is increasingly prevalent, with hyperuricemia contributing to its progression by promoting inflammation, oxidative stress, and insulin resistance.High uric acid levels are linked to more severe CLD and poorer outcomes.This study aims to evaluate serum uric acid levels and their significance in patients with chronic liver disease. Materials and Methods:Following IEC approval, 120 patients with chronic liver disease (CLD) from various causes (excluding factors affecting uric acid levels) were included.Patient symptoms, physical exams, serum uric acid, and liver function tests were documented, and the Child-Turcotte-Pugh (CTP) score was calculated.Statistical analysis assessed associations between uric acid levels, CLD causes, and disease severity.Results: Of the 120 patients, 70% were male with an average age of 46.22 years.Alcoholic liver disease was the leading cause (52.5%), followed by chronic hepatitis B (22.5%).Serum uric acid levels showed a significant correlation with the Child-Turcotte-Pugh (CTP) score (p = 0.010), with higher levels in hepatitis B patients and those in CTP class C. Significant associations were also noted between uric acid and albumin, bilirubin, INR, SGOT, and SGPT levels.(P<0.05) Conclusions:The study indicates that elevated serum uric acid levels correlate with higher Child-Pugh scores, suggesting it as a reliable, cost-effective marker for assessing liver cirrhosis severity.This non-invasive marker can aid in early intervention and monitoring of chronic liver disease.