A Comparative Study of Morning & Evening Doses of Telmisartan in Patients of Hypertension in A Tertiary Care Hospital: A Prospective Observational Study

Background: Hypertension is a major global health issue that elevates the risk of cardiovascular diseases, particularly in India, where a significant portion of adults is affected, resulting in high morbidity and mortality.Despite advancements in treatment, effective management strategies are still needed.This study focuses on telmisartan, an angiotensin II receptor blocker (ARB) commonly used for essential hypertension, examining the effects of administering it in the evening versus the morning to improve blood pressure control and patient adherence by aligning with the body's natural circadian rhythms. Materials & Methods:A prospective observational study was conducted involving 340 newly diagnosed hypertensive patients.Participants were randomly assigned to receive telmisartan either in the morning or evening.Blood pressure measurements and laboratory investigations were performed at baseline and follow-ups (1, 4, and 12 weeks). Results:The evening dosing group showed significantly greater reductions in both systolic and diastolic blood pressure compared to the morning group (P<0.05).Additionally, the evening group had better adherence rates.Clinical parameters, including sodium and potassium levels, were also assessed, showing significant differences in electrolyte levels but no notable changes in urea or creatinine. Conclusion:Administering telmisartan in the evening provides significant advantages, including better blood pressure control and adherence to treatment, while aligning with the body's circadian rhythms.This timing should be considered when prescribing telmisartan for hypertension management.