Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma
Our findings offer a potential therapeutic strategy to maintain a dynamic balance within the TME and improve the immunotherapy efficacy by modulating the relative proportions and functional states of CXCL9 + TAMs and TREM2 + TAMs.
Authors
- Jingshan Tong (ORCID: https://orcid.org/0000-0003-1640-5769)
- Ping Xiao (ORCID: https://orcid.org/0000-0001-5678-501X)
- Jiali Ren (ORCID: https://orcid.org/0009-0009-6974-8731)
- Fengming You (ORCID: https://orcid.org/0000-0001-7900-4060)
- Peng Wu (ORCID: https://orcid.org/0000-0002-0186-1086)
- Jiawei He (ORCID: https://orcid.org/0000-0003-1636-1823)
- Shiyan Tan
- Heng-Zhou Lai
- Yifeng Ren (ORCID: https://orcid.org/0000-0003-2976-4250)
- Fang Li (ORCID: https://orcid.org/0000-0001-8083-4002)
- Fu Xi (ORCID: https://orcid.org/0000-0002-3495-6145)
- Zhong Yang (ORCID: https://orcid.org/0000-0002-9113-9635)
- Xiang Zhuang (ORCID: https://orcid.org/0000-0002-0253-1476)
- Hua Jiang (ORCID: https://orcid.org/0000-0003-1516-9952)
- Chunxia Huang (ORCID: https://orcid.org/0000-0002-3610-6400)
- Chuan Zheng (ORCID: https://orcid.org/0000-0002-9181-2383)
- Liting You
- Xiao Zeng
- Qiong Ma
- Longfei Zhang (ORCID: https://orcid.org/0009-0002-6086-2270)
- Wei Shi (ORCID: https://orcid.org/0009-0004-5305-4130)
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
- Hangzhou DAC Biotech (China) (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-11-23
- DOI
- https://doi.org/10.1186/s12943-024-02177-7
- Citations
- 24
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 10.05