Formulation and Evaluation of Mucoadhesive Microspheres Loaded Intra-Nasal Gel of An Anti-Psychotic Drug

Aim:The objective of the present study is to design and evaluate mucoadhesive microspheres loaded Intra nasal gel for brain targeting. Materials and methods:Clozapine microspheres containing different concentration of mucoadhesive polymers i.e.Hydroxy propyl cellulose (HPC), Xanthan gum, Carboxy methyl cellulose (CMC) were prepared using ion gelation method.The optimized microspheres were selected for the preparation of Nasal gel using different concentrations of Carbopol 934 and underwent various evaluation parameters. Results:The prepared optimized microsphere formulation was spherical.The % entrapment efficiency was 92.2% for formulation 6 and showed excellent mucoadhesive property.The drug release of formulation 8 was slow and extended over 12hrs of duration.The prepared optimized gel formulation showed good gel strength with 87.8% of drug content and the drug release was found to be extended over 12hrs of duration and fitted to different kinetics models following first order. Conclusion:The prepared microspheres loaded nasal gel are thus suitable for nasal administration and helps in avoiding first pass metabolism giving drug release for extended period of time.