Discrepancies between pre-specified and reported primary outcomes: A cross-sectional analysis of randomized controlled trials in gastroenterology and hepatology journals
This study highlights the disparities between registered and published primary outcomes in RCTs within gastroenterology and hepatology journals. Attention to factors such as the timing of primary outcome assessments in published trials and the consistency between registered and published primary outcomes is crucial. Enhanced scrutiny from journal editors and peer reviewers during the review process is necessary to ensure the reliability of gastrointestinal and hepatic trials.
Authors
- Szymon Białka (ORCID: https://orcid.org/0000-0002-5923-2469)
- Kaiping Zhang
- Dina Christa Janse van Rensburg
- Sheikh Mohammed Shariful Islam (ORCID: https://orcid.org/0000-0001-7926-9368)
- Lin Yao (ORCID: https://orcid.org/0000-0002-5948-2249)
- Caroline Rhéaume (ORCID: https://orcid.org/0000-0002-1863-4410)
- Izumi Kawagoe (ORCID: https://orcid.org/0000-0002-5791-2700)
- F C Yang
- Adriano R. Tonelli (ORCID: https://orcid.org/0000-0002-2321-9545)
- Binghan Shang
Institutions
- Cleveland Clinic (US)
- Deakin University (AU)
- Medical University of Silesia (PL)
- Nantong University (CN)
- Juntendo University (JP)
- Advanced Materials Enterprises (China) (CN)
- Université Laval (CA)
- University of Pretoria (ZA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1371/journal.pone.0305027
- Citations
- 2
- Primary Topic
- Meta-analysis and systematic reviews
- Type
- article
- Field-Weighted Citation Impact
- 0.92