Spatial distributions of CD8 and Ki67 cells in the tumor microenvironment independently predict breast cancer-specific survival in patients with ER+HER2– and triple-negative breast carcinoma
Computational biomarkers, representing spatial properties of the tumor proliferation and immune cell infiltrates, provided independent prognostic information beyond conventional IHC markers in BC. Integrating Ki67-entropy and CD8-immunogradient indicators into prognostic models can improve patient stratification with regard to BCSS.
Authors
- Allan G. Rasmusson (ORCID: https://orcid.org/0000-0001-6705-6795)
- Ruta Barbora Valkiuniene
- Dovile Zilenaite-Petrulaitiene (ORCID: https://orcid.org/0000-0002-7221-2868)
- Linas Petkevičius (ORCID: https://orcid.org/0000-0003-2416-0431)
- Arvydas Laurinavičius (ORCID: https://orcid.org/0000-0001-9232-1730)
- Aida Laurinavičienė
Institutions
- Vilnius University (LT)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1371/journal.pone.0314364
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Lietuvos Mokslo Taryba