Long-term visual outcomes and histopathologic findings after cataract surgery in Ebola virus disease survivors in the Ebola virus RNA persistence in ocular tissues and fluids (EVICT) study
Ebola virus disease (EVD) survivors may develop several ophthalmic sequelae including uveitis and cataract that may lead to severe vision loss if left untreated. Manual small incision cataract surgery (MSICS) has been utilized to treat cataract in EVD survivors with encouraging short-term outcomes, but the long-term visual acuity outcomes and the potential for Ebola virus RNA to reside in cataract material is unknown. In this study, we reported long-term visual acuity outcomes following MSICS in a cohort of EVD survivors along with histopathology findings from materials collected during surgery. Visual acuity improved over 12-month follow-up with encouraging safety measures. Ebola virus RNA was not detected in cataract and lens capsular tissue analyzed from EVD survivors. This study provides additional assurance regarding the safety and efficacy of cataract surgery, with potential for improved vision for EVD survivors.
Authors
- Xiankun Zeng (ORCID: https://orcid.org/0000-0003-3526-8755)
- John S. Schieffelin (ORCID: https://orcid.org/0000-0001-6642-5739)
- Robert F. Garry (ORCID: https://orcid.org/0000-0002-5683-3250)
- Donald Samuel Grant (ORCID: https://orcid.org/0000-0002-4329-0795)
- Colleen S. Kraft (ORCID: https://orcid.org/0000-0003-1757-8477)
- Jalikatu Mustapha (ORCID: https://orcid.org/0000-0003-3260-5170)
- Matthew Jusu Vandy (ORCID: https://orcid.org/0000-0002-8612-5845)
- Brent Hayek (ORCID: https://orcid.org/0000-0002-6632-8047)
- John G. Mattia
- Lucas Kim
- Ian Crozier (ORCID: https://orcid.org/0000-0003-2485-4011)
- Steven Yeh (ORCID: https://orcid.org/0000-0002-5417-7771)
- Tolulope Fashina (ORCID: https://orcid.org/0000-0001-9024-9202)
- Lloyd Harrison-Williams (ORCID: https://orcid.org/0000-0002-0556-6607)
- Jessica G. Shantha (ORCID: https://orcid.org/0000-0002-4449-8598)
- Caleb Hartley (ORCID: https://orcid.org/0000-0002-8259-2518)
- Gustavo Palacios (ORCID: https://orcid.org/0000-0001-5062-1938)
- Jack Begley
- Augustine Goba
Institutions
- Tulane University (US)
- Emory University (US)
- University of California, San Francisco (US)
- University of Sierra Leone (SL)
- United States Army Medical Research Institute of Infectious Diseases (US)
- San Francisco Foundation (US)
- Georgia Urology (US)
- Ministry of Health and Sanitation (SL)
- Frederick National Laboratory for Cancer Research (US)
- University of Nebraska Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1371/journal.pntd.0012662
- Citations
- 1
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- U.S. Department of Health and Human Services
- Association for Research in Vision and Ophthalmology
- Edward Mallinckrodt, Jr. Foundation
- Retina Research Foundation
- National Institutes of Health
- National Cancer Institute