Intermittent or Continuous Panitumumab Plus Fluorouracil, Leucovorin, and Irinotecan for First-Line Treatment of <i>RAS</i> and <i>BRAF</i> Wild-Type Metastatic Colorectal Cancer: The IMPROVE Trial
Intermittent FOLFIRI plus PAN after the induction phase was feasible, and the primary end point was met with reduced toxicity while allowing patients more time off treatment.
Authors
- Vincenzo Montesarchio (ORCID: https://orcid.org/0000-0001-5545-8105)
- Alfredo Colombo (ORCID: https://orcid.org/0000-0001-6902-5028)
- Gerardo Rosati (ORCID: https://orcid.org/0000-0001-7004-6862)
- Giuseppe Santabarbara
- Emiliano Tamburini (ORCID: https://orcid.org/0000-0003-4619-7091)
- Antonella Petrillo (ORCID: https://orcid.org/0000-0003-2465-5370)
- Alfredo Budillon (ORCID: https://orcid.org/0000-0002-6330-6053)
- Alfonso De Stefano (ORCID: https://orcid.org/0000-0003-2107-1177)
- Paolo Delrio (ORCID: https://orcid.org/0000-0002-4271-4939)
- Silvana Leo
- Francesco Mannavola (ORCID: https://orcid.org/0000-0003-2623-4166)
- Carmela Romano (ORCID: https://orcid.org/0000-0003-1796-9873)
- Lucrezia Silvestro (ORCID: https://orcid.org/0000-0002-4209-7694)
- Alessandra Leone (ORCID: https://orcid.org/0000-0002-1051-2937)
- Mariapia Laterza
- Antonio Febbraro
- Guglielmo Nasti (ORCID: https://orcid.org/0000-0002-3590-382X)
- Claudio Lotesoriere (ORCID: https://orcid.org/0000-0002-7999-9739)
- Antonino Cassata
- Francesco Giuliani (ORCID: https://orcid.org/0000-0002-5707-2158)
- Diana Giannarelli (ORCID: https://orcid.org/0000-0002-6085-1195)
- Antonio Avallone (ORCID: https://orcid.org/0000-0001-6188-5664)
- Francesco Izzo (ORCID: https://orcid.org/0000-0003-3093-5408)
- Alberto F. Sobrero (ORCID: https://orcid.org/0000-0001-5483-4412)
- Daniele Santini (ORCID: https://orcid.org/0000-0002-9118-3337)
- Anna Giulia Nappi (ORCID: https://orcid.org/0000-0002-9046-6378)
Institutions
- Policlinico Umberto I (IT)
- Agostino Gemelli University Polyclinic (IT)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- Ospedale Monaldi (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Ospedale Policlinico San Martino (IT)
- Ospedale Vito Fazzi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- ASST Fatebenefratelli Sacco (IT)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1200/jco.24.00979
- Citations
- 8
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- Amgen