Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles
Our study demonstrates that extracellular vesicles secreted by the gut microbiota can influence the nervous system via the microbial-gut-brain axis. Furthermore, we found that the extracellular vesicles secreted by the gut microbiota from the probiotic group exert a beneficial therapeutic effect on anxiety and hippocampal neuroinflammation.
Authors
- Huiya Yuan
- Xiaohuan Chen (ORCID: https://orcid.org/0000-0002-0927-0715)
- Changliang Wang (ORCID: https://orcid.org/0000-0001-9561-3499)
- Yuanyuan Guo (ORCID: https://orcid.org/0000-0002-2208-6269)
- Fanyue Meng
- Jeanne Tie (ORCID: https://orcid.org/0000-0001-9244-2057)
- Chaoxu Zhang
- Guohua Zhang (ORCID: https://orcid.org/0000-0003-0622-2440)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0002-3987-6638)
- Hao Liu (ORCID: https://orcid.org/0000-0001-9176-4425)
- Hao Yu (ORCID: https://orcid.org/0000-0002-2833-6441)
- Chenyang Yu (ORCID: https://orcid.org/0000-0003-4224-5658)
- Xu Wu (ORCID: https://orcid.org/0000-0003-3757-5767)
- Hui Shen (ORCID: https://orcid.org/0000-0002-9508-0562)
- Jiaxin Pei
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5975-9781)
Institutions
- Liaoning University (CN)
- The Supreme People's Procuratorate of the People's Republic of China (CN)
- General Hospital of Shenyang Military Region (CN)
- Institute of Forensic Science (CN)
- First Hospital of China Medical University (CN)
- Jinzhou Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s12951-024-03017-y
- Citations
- 21
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.91
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Liaoning Province