Comparative adverse event profiles of triplet therapy versus docetaxel-based therapy in patients with metastatic prostate cancer: a multicenter retrospective study
This study represents the first real-world analysis comparing the adverse event profiles of triplet therapy and docetaxel-based therapy in Japanese patients with mCSPC, as well as docetaxel-based therapy in those with mCRPC. No significant difference in severe AEs was observed between the therapies. Primary prophylaxis with G-CSF proved critical in reducing severe neutropenia and FN, underscoring its importance in enhancing the safety and efficacy of docetaxel-based therapies.
Authors
- Kenichi Hata (ORCID: https://orcid.org/0000-0002-6857-7354)
- Taro Igarashi (ORCID: https://orcid.org/0000-0002-5624-7614)
- Hiroki Yamada (ORCID: https://orcid.org/0000-0003-2987-7829)
- Masaki Hashimoto (ORCID: https://orcid.org/0000-0002-0396-8223)
- Fumihiko Urabe (ORCID: https://orcid.org/0000-0002-2599-8183)
- Kosuke Iwatani (ORCID: https://orcid.org/0000-0001-5428-852X)
- Wataru Fukuokaya (ORCID: https://orcid.org/0000-0003-1044-912X)
- Jun Miki (ORCID: https://orcid.org/0000-0002-4638-8640)
- Masaya Murakami (ORCID: https://orcid.org/0000-0002-1268-6615)
- Takafumi Yanagisawa (ORCID: https://orcid.org/0000-0002-7410-0712)
- Kojiro Tashiro
- Shuhei Hara (ORCID: https://orcid.org/0009-0001-9842-3612)
- Shunsuke Tsuzuki
- Yu Imai (ORCID: https://orcid.org/0000-0003-0971-4205)
- Mahito Atsuta
- Hidetsugu Takahashi
- Brendan A. Yanada (ORCID: https://orcid.org/0000-0001-7962-8201)
- Takahiro Kimura
- Hirokazu Kagawa
- Toshihiro Yamamoto
Institutions
- Jikei University School of Medicine (JP)
- The University of Melbourne (AU)
- Katsushika Medical Center (JP)
- The Jikei University Hospital (JP)
- Fujieda Municipal General Hospital (JP)
- Jikei University Kashiwa hospital (JP)
Publication Details
- Journal
- Prostate International
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1016/j.prnil.2024.11.003
- Citations
- 4
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.68