Reprogrammed human lateral ganglionic eminence precursors generate striatal neurons and restore motor function in a rat model of Huntington’s disease
This study provides proof-of-concept and demonstrates for the first time that aHDFs can be directly reprogrammed to hiLGEPs which survive transplantation, undergo neuronal differentiation to generate medium spiny-like striatal neurons, and reduce functional impairment in the QA lesion rat model of HD.
Authors
- Bronwen Connor (ORCID: https://orcid.org/0000-0001-6828-4175)
- Amy McCaughey‐Chapman (ORCID: https://orcid.org/0000-0002-3177-2658)
- Catharina Combrinck
- David Gordon (ORCID: https://orcid.org/0000-0002-9764-1968)
- Laura Marriott
- Anne Lieke Burgers
Institutions
- University of Auckland (NZ)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s13287-024-04057-9
- Citations
- 2
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Maurice and Phyllis Paykel Trust
- Health Research Council of New Zealand