Depletion of regulatory T cells enhances the T cell response induced by the neoantigen vaccine with weak immunogenicity
Our research first revealed that inhibiting the normal function of Tregs transformed "weaker" neoantigens into "stronger" ones, while also contributing to the proliferation of NRT cells. This Treg-depleting strategy allowed neoantigens with poor immunogenicity to elicit a robust immune response, thereby augmenting the efficacy of the neoantigen vaccine in delaying tumor growth and prolonging the survival of the hosts.
Authors
- Yanfang Liu (ORCID: https://orcid.org/0000-0002-2923-0729)
- Hao Qin (ORCID: https://orcid.org/0000-0002-5753-5060)
- Ruichen Huang
- Yuchao Dong
- Xiuyan Song
- Wei Zhang (ORCID: https://orcid.org/0000-0001-5292-7308)
- Jun Wang (ORCID: https://orcid.org/0000-0001-6822-2863)
- Xia Yang
- Lan Cheng (ORCID: https://orcid.org/0000-0003-2034-5586)
- Hong‐Hao Zhou (ORCID: https://orcid.org/0000-0003-4252-3304)
- Qiao Zhou (ORCID: https://orcid.org/0000-0001-5929-5438)
- Tangtao Feng
- Bi Zhao (ORCID: https://orcid.org/0000-0003-0962-4752)
- Yang Jiao (ORCID: https://orcid.org/0000-0001-5971-9907)
- Qinying Sun
- Jiajun Liu (ORCID: https://orcid.org/0009-0001-3677-613X)
- Yunye Ning
- Xiaoping Su
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- Ruijin Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1016/j.neo.2024.101088
- Citations
- 6
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Shanghai Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines