Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice
In conclusion, chrysophanol demonstrated remarkable neuroprotective and antiepileptic effects at a dose of 10 mg/kg in stress-exacerbated PTZ-induced epilepsy following the TLR4/NFκB -Nrf2/HO-1 and BDNF/VEGF pathways.
Authors
- Mujeeb Ur Rehman (ORCID: https://orcid.org/0000-0002-5078-5657)
- Muhammad Khalid Tipu (ORCID: https://orcid.org/0000-0003-2041-9557)
- Najeeb Ur Rehman (ORCID: https://orcid.org/0000-0001-6925-7697)
- Fawad Ali Shah (ORCID: https://orcid.org/0000-0002-5415-2179)
- Syeda Rida Zainab
- Muhammad Abid (ORCID: https://orcid.org/0009-0002-6256-0559)
- Jehanzeb Khan (ORCID: https://orcid.org/0000-0001-8140-774X)
Institutions
- Quaid-i-Azam University (PK)
- Prince Sattam Bin Abdulaziz University (SA)
- Iqra University (PK)
- University of Swat (PK)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3389/fphar.2024.1446304
- Citations
- 11
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.57