Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans
Increased levels of p-tau231 are associated with impaired generalization abilities and reduced dynamic network flexibility within the MTL. Plasma p-tau231 may serve as a potential biomarker for assessing cognitive decline and neural changes in cognitively unimpaired older African Americans.
Authors
- Miray Budak (ORCID: https://orcid.org/0000-0003-0552-8464)
- Robert Perna
- Bernadette A. Fausto (ORCID: https://orcid.org/0000-0002-8412-1023)
- Mark A. Gluck (ORCID: https://orcid.org/0000-0003-0538-2303)
- Mustafa Sheikh
- Zuzanna Osiecka
- Nicholas J. Ashton
- Patricia Fitzgerald-Bocarsly
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Wisconsin–Madison (US)
- Hong Kong University of Science and Technology (HK)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- University Hospital, Newark (US)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Rutgers Health (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s13195-024-01619-0
- Citations
- 7
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- National Institute on Aging