TLR7 rs179008 (A/T) and TLR7 rs3853839 (C/G) polymorphisms are associated with variations in IFN-α levels in HTLV-1 infection
Although the polymorphisms did not influence the presence of symptoms of diseases caused by HTLV-1, carriers of the wild-type alleles for <i>TLR7</i> rs179008 (A/T) and the polymorphism for <i>TLR7</i> rs3853839 (C/G) appears to have a stronger antiviral response and increased infection control.
Authors
- Ricardo Ishak (ORCID: https://orcid.org/0000-0002-4741-6201)
- Felipe Teixeira Lopes
- Antônio Carlos Rosário Vallinoto (ORCID: https://orcid.org/0000-0003-1135-6507)
- Izaura Maria Vieira Cayres Vallinoto (ORCID: https://orcid.org/0000-0003-1408-8384)
- Sandra Souza Lima (ORCID: https://orcid.org/0000-0001-5137-7770)
- Maria Alice Freitas Queiroz (ORCID: https://orcid.org/0000-0003-2014-2770)
- Wandrey Roberto dos Santos Brito
- Gabriel dos Santos Pereira Neto (ORCID: https://orcid.org/0000-0002-7825-9384)
- F. Ferreira (ORCID: https://orcid.org/0000-0002-2225-1674)
- Aline Cecy Rocha de Lima (ORCID: https://orcid.org/0000-0001-5887-3689)
- Marco Túlio de Souza (ORCID: https://orcid.org/0000-0003-3133-4778)
- Carlos Araújo da Costa (ORCID: https://orcid.org/0000-0003-2662-3989)
- Emmanuelle Giuliana Mendes Santana
- Ednelza da Silva Graça Amoras
Institutions
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3389/fimmu.2024.1462352
- Citations
- 7
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico