Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis
GAS alleviated pathological changes in the hearts of DCM model mice induced by an HSF diet combined with STZ. KLK8 mediated HG-PA-induced differentiation, collagen synthesis, and the migration of CFs. GAS attenuated the differentiation, collagen synthesis, and migration of CFs by inhibiting the KLK8-PAR1 signaling axis, a process in which TGF-β1 and Smad3 are involved.
Authors
- Y M Wang
- Xiangchun Shen (ORCID: https://orcid.org/0000-0002-4333-9106)
- Yufei Zhang (ORCID: https://orcid.org/0000-0003-1209-8730)
- Ling Tao (ORCID: https://orcid.org/0000-0003-4043-7146)
- Xinrui Wang (ORCID: https://orcid.org/0000-0001-7003-4917)
- Linyan Li (ORCID: https://orcid.org/0000-0003-4031-6352)
- Jinggang He
- Min Zhang (ORCID: https://orcid.org/0000-0002-3679-1241)
- MingShan Zhang
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1186/s13020-024-01035-4
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- Dalian High-Level Talent Innovation Program
- National Natural Science Foundation of China
- Guizhou Science and Technology Department