A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights
Although the incidence of cervical cancer (CC) has been reduced in high-income countries due to human papillomavirus (HPV) vaccination and screening strategies, it remains a significant public health issue that poses a threat to women's health in low-income countries. Here, we perform a comprehensive proteogenomic profiling of CC tumors obtained from 139 Chinese women. Integrated proteogenomic analysis links genetic aberrations to downstream pathogenesis-related pathways and reveals the landscape of HPV-associated multi-omic changes. EP300 is found to enhance the acetylation of FOSL2-K222, consequently accelerating the malignant proliferation of CC cells. Proteomic stratification identifies three patient subgroups with distinct features in prognosis, genetic alterations, immune infiltration, and post-translational modification regulations. PRKCB is further identified as a potential radioresponse-related biomarker of CC patients. This study provides a valuable public resource for researchers and clinicians to delve into the molecular basis of CC, to identify potential treatments and to ultimately advance clinical practice.
Authors
- Jiaming Guo (ORCID: https://orcid.org/0000-0002-8189-846X)
- Zhicheng Yang (ORCID: https://orcid.org/0000-0001-7477-2984)
- Yansheng Liu (ORCID: https://orcid.org/0000-0002-2626-3912)
- Xiuqi Gui (ORCID: https://orcid.org/0009-0002-7680-477X)
- Guangwen Yuan (ORCID: https://orcid.org/0000-0001-8480-3596)
- Xiaoxian Du
- Lu Deng
- Ana I. Robles (ORCID: https://orcid.org/0000-0001-5019-4374)
- Lingying Wu
- Shuhan Zhou (ORCID: https://orcid.org/0000-0002-7131-5144)
- Henry Rodriguez (ORCID: https://orcid.org/0000-0002-4593-4232)
- Daming Gao (ORCID: https://orcid.org/0000-0003-4374-1055)
- Hu Zhou (ORCID: https://orcid.org/0000-0001-7006-4737)
- Qian Liu (ORCID: https://orcid.org/0000-0003-2510-3113)
- Ning Li (ORCID: https://orcid.org/0000-0002-3266-3322)
- Bing Zhang (ORCID: https://orcid.org/0000-0001-8676-2425)
- Li Ding (ORCID: https://orcid.org/0000-0003-1517-2975)
- Pei Wang (ORCID: https://orcid.org/0000-0002-6890-6453)
- Xianming Liu (ORCID: https://orcid.org/0000-0001-7752-1136)
- Jing Zuo (ORCID: https://orcid.org/0000-0002-1202-9439)
- Jing Yu (ORCID: https://orcid.org/0000-0002-8694-8948)
- Zhen Shao (ORCID: https://orcid.org/0000-0002-4934-4360)
- Xuan Guo (ORCID: https://orcid.org/0000-0001-8560-6076)
- Yuxi Zhao (ORCID: https://orcid.org/0000-0002-3718-6406)
- Yan Song (ORCID: https://orcid.org/0000-0002-1720-227X)
- Yi‐Min Chen
- Jia Zeng (ORCID: https://orcid.org/0000-0002-9447-2791)
- Yanmei Zou
- Jia Jia (ORCID: https://orcid.org/0000-0002-5504-2801)
- Kaihua Wang
- Manni Huang (ORCID: https://orcid.org/0000-0002-9158-7518)
- Jusheng An
Institutions
- James S. McDonnell Foundation (US)
- National Institutes of Health (US)
- Baylor College of Medicine (US)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Yale Cancer Center (US)
- Yale University (US)
- National Cancer Center (US)
- Shanghai Institute of Nutrition and Health (CN)
- Bruker (China) (CN)
- Shanghai Institute of Materia Medica (CN)
- Center for Excellence in Molecular Cell Science (CN)
- ZheJiang Academy of Agricultural Sciences (CN)
- Institute for Advanced Study (DE)
- National Cancer Institute (US)
- University of Chinese Academy of Sciences (CN)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-11-22
- DOI
- https://doi.org/10.1038/s41467-024-53830-0
- Citations
- 15
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 5.80
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China
- National Cancer Institute