A rare presentation of rhabdomyolysis-associated acute kidney injury and hepatocellular dysfunction with persistent proximal weakness of lower limb

Exercise-induced rhabdomyolysis (ERM) is a pathophysiological condition where skeletal muscles break down, releasing their contents into the bloodstream. Common complications include acute kidney injury (AKI), compartment syndrome, and disseminated intravascular coagulation, with AKI being the most serious. Rarely, ERM may also be associated with hepatocellular dysfunction, leading to confusion in diagnosis. The reason for elevated liver enzymes in this condition is not yet fully understood. In addition, persistent weakness in the lower limbs after rhabdomyolysis is rarely reported. In this particular case, the patient presented with these symptoms for the first time, prompting consideration of inherited metabolic disorders and genetic mutations. This case study highlights a rare instance of hepatocellular dysfunction and persistent limb weakness resulting from ERM, which necessitated prolonged dialysis for renal recovery.