Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes
In summary, we identified two subtypes, including the AD early synaptic abnormality subtype as well as the immune-metabolic subtype. Additionally, ten hub genes, SLC17A7, SNAP25, GAD1, SLC17A6, SLC32A1, PVALB, SYP, GRIN2A, SLC12A5, and SYN2, were identified as marker genes for the early subtype. These findings may provide valuable insights for the early diagnosis of AD and contribute to the development of innovative therapeutic strategies.
Authors
- Liumei Zhang (ORCID: https://orcid.org/0000-0002-1834-5424)
- Wen-Xu Wang (ORCID: https://orcid.org/0000-0002-4170-8676)
- J P Li (ORCID: https://orcid.org/0000-0002-1598-2188)
- Cheng Chi (ORCID: https://orcid.org/0000-0001-5603-0610)
- Mingjie Zhang (ORCID: https://orcid.org/0000-0001-9404-0190)
- Liang Frank Wang (ORCID: https://orcid.org/0000-0002-3771-4627)
- Huiying Zhang (ORCID: https://orcid.org/0000-0002-5528-4712)
- Jincheng Lu
- Jianliang Dai (ORCID: https://orcid.org/0009-0003-0964-9287)
- Ningyun Pan (ORCID: https://orcid.org/0000-0002-8772-2596)
Institutions
- Xuzhou Medical College (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- Shandong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-22
- DOI
- https://doi.org/10.3389/fimmu.2024.1462003
- Citations
- 11
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.61